Excitotoxic lateral pallidotomy does not relieve L-DOPA-induced dyskinesia in MPTP parkinsonian monkeys
Identifieur interne : 004302 ( Main/Exploration ); précédent : 004301; suivant : 004303Excitotoxic lateral pallidotomy does not relieve L-DOPA-induced dyskinesia in MPTP parkinsonian monkeys
Auteurs : P. J. Blanchet [Canada] ; R. Boucher [Canada] ; P. J. BedardSource :
- Brain research [ 0006-8993 ] ; 1994.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Singe.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animal, Animals, Antiparkinson agent, Dopa, Dyskinesia, Dyskinesia, Drug-Induced (etiology), Experimental disease, Female, Globus Pallidus (physiopathology), Globus Pallidus (surgery), Lesion, Levodopa, Macaca fascicularis, Monkey, Neurotoxin, Pallidum, Parkinson Disease, Secondary (etiology), Parkinson Disease, Secondary (physiopathology), Parkinson disease, Prevention.
- MESH :
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Levodopa.
- etiology : Dyskinesia, Drug-Induced, Parkinson Disease, Secondary.
- physiopathology : Globus Pallidus, Parkinson Disease, Secondary.
- surgery : Globus Pallidus.
- Animals, Female, Macaca fascicularis.
Abstract
We attempted to relieve the marked overactivity known to occur in the lateral segment of the globus pallidus (GPL) in L-DOPA-induced dyskinesia (LID) by unilateral stereotaxic ibotenic acid lesioning of the GPL in 4 monkeys with MPTP-induced parkinsonism. Two already dyskinetic animals were pallidotomized to counteract LID once established, while 2 L-DOPA-naive MPTP-treated animals were pallidotomized before L-DOPA was ever administered in an attempt to prevent the development of the process conducive to LID. Acutely after the lesion, more prominent akinesia (particularly in the contralateral limbs) with contraversive body deviation and circling behavior were seen for 48 h
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 001012
- to stream PascalFrancis, to step Curation: 000F13
- to stream PascalFrancis, to step Checkpoint: 000F10
- to stream Main, to step Merge: 004A72
- to stream PubMed, to step Corpus: 001961
- to stream PubMed, to step Curation: 001961
- to stream PubMed, to step Checkpoint: 001961
- to stream Ncbi, to step Merge: 002438
- to stream Ncbi, to step Curation: 002438
- to stream Ncbi, to step Checkpoint: 002438
- to stream Main, to step Merge: 004870
- to stream Main, to step Curation: 004302
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Excitotoxic lateral pallidotomy does not relieve L-DOPA-induced dyskinesia in MPTP parkinsonian monkeys</title><author><name sortKey="Blanchet, P J" sort="Blanchet, P J" uniqKey="Blanchet P" first="P. J." last="Blanchet">P. J. Blanchet</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hôp. Enfant-Jésus, neurobiology res. cent.</s1><s2>Québec PQ G1J 7Z4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec PQ G1J 7Z4</wicri:noRegion></affiliation></author><author><name sortKey="Boucher, R" sort="Boucher, R" uniqKey="Boucher R" first="R." last="Boucher">R. Boucher</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hôp. Enfant-Jésus, neurobiology res. cent.</s1><s2>Québec PQ G1J 7Z4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec PQ G1J 7Z4</wicri:noRegion></affiliation></author><author><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P. J." last="Bedard">P. J. Bedard</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">94-0505468</idno><date when="1994">1994</date><idno type="stanalyst">PASCAL 94-0505468 INIST</idno><idno type="RBID">Pascal:94-0505468</idno><idno type="wicri:Area/PascalFrancis/Corpus">001012</idno><idno type="wicri:Area/PascalFrancis/Curation">000F13</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000F10</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000F10</idno><idno type="wicri:doubleKey">0006-8993:1994:Blanchet P:excitotoxic:lateral:pallidotomy</idno><idno type="wicri:Area/Main/Merge">004A72</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:7953674</idno><idno type="wicri:Area/PubMed/Corpus">001961</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001961</idno><idno type="wicri:Area/PubMed/Curation">001961</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001961</idno><idno type="wicri:Area/PubMed/Checkpoint">001961</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001961</idno><idno type="wicri:Area/Ncbi/Merge">002438</idno><idno type="wicri:Area/Ncbi/Curation">002438</idno><idno type="wicri:Area/Ncbi/Checkpoint">002438</idno><idno type="wicri:doubleKey">0006-8993:1994:Blanchet P:excitotoxic:lateral:pallidotomy</idno><idno type="wicri:Area/Main/Merge">004870</idno><idno type="wicri:Area/Main/Curation">004302</idno><idno type="wicri:Area/Main/Exploration">004302</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Excitotoxic lateral pallidotomy does not relieve L-DOPA-induced dyskinesia in MPTP parkinsonian monkeys</title><author><name sortKey="Blanchet, P J" sort="Blanchet, P J" uniqKey="Blanchet P" first="P. J." last="Blanchet">P. J. Blanchet</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hôp. Enfant-Jésus, neurobiology res. cent.</s1><s2>Québec PQ G1J 7Z4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec PQ G1J 7Z4</wicri:noRegion></affiliation></author><author><name sortKey="Boucher, R" sort="Boucher, R" uniqKey="Boucher R" first="R." last="Boucher">R. Boucher</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hôp. Enfant-Jésus, neurobiology res. cent.</s1><s2>Québec PQ G1J 7Z4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec PQ G1J 7Z4</wicri:noRegion></affiliation></author><author><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P. J." last="Bedard">P. J. Bedard</name></author></analytic><series><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain res.</title><idno type="ISSN">0006-8993</idno><imprint><date when="1994">1994</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain res.</title><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Animal</term><term>Animals</term><term>Antiparkinson agent</term><term>Dopa</term><term>Dyskinesia</term><term>Dyskinesia, Drug-Induced (etiology)</term><term>Experimental disease</term><term>Female</term><term>Globus Pallidus (physiopathology)</term><term>Globus Pallidus (surgery)</term><term>Lesion</term><term>Levodopa</term><term>Macaca fascicularis</term><term>Monkey</term><term>Neurotoxin</term><term>Pallidum</term><term>Parkinson Disease, Secondary (etiology)</term><term>Parkinson Disease, Secondary (physiopathology)</term><term>Parkinson disease</term><term>Prevention</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Globus Pallidus</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Globus Pallidus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Macaca fascicularis</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dopa</term><term>Neurotoxine</term><term>Parkinson maladie</term><term>Dyskinésie</term><term>Prévention</term><term>Lésion</term><term>Pallidum</term><term>Antiparkinsonien</term><term>Pathologie expérimentale</term><term>Animal</term><term>Singe</term><term>MPTP</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Singe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We attempted to relieve the marked overactivity known to occur in the lateral segment of the globus pallidus (GP<sub>L</sub>) in L-DOPA-induced dyskinesia (LID) by unilateral stereotaxic ibotenic acid lesioning of the GP<sub>L</sub> in 4 monkeys with MPTP-induced parkinsonism. Two already dyskinetic animals were pallidotomized to counteract LID once established, while 2 L-DOPA-naive MPTP-treated animals were pallidotomized before L-DOPA was ever administered in an attempt to prevent the development of the process conducive to LID. Acutely after the lesion, more prominent akinesia (particularly in the contralateral limbs) with contraversive body deviation and circling behavior were seen for 48 h</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P. J." last="Bedard">P. J. Bedard</name></noCountry><country name="Canada"><noRegion><name sortKey="Blanchet, P J" sort="Blanchet, P J" uniqKey="Blanchet P" first="P. J." last="Blanchet">P. J. Blanchet</name></noRegion><name sortKey="Boucher, R" sort="Boucher, R" uniqKey="Boucher R" first="R." last="Boucher">R. Boucher</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004302 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004302 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:94-0505468
|texte= Excitotoxic lateral pallidotomy does not relieve L-DOPA-induced dyskinesia in MPTP parkinsonian monkeys
}}
| This area was generated with Dilib version V0.6.29. |  |